TURBLOX -250


Terbinafine 250 mg

10X1X7 BLISTER) Rs 155

TURBLOX -250

It belongs to the class of antifungal drugs and is also known as synthetic allyl amine. It is lipophilic in nature and accumulated in the nails, skin and fatty tissues thus exerts its antifungal action.
It has longer duration of action.

  • Treats infections caused by candida
  • Treats fungal infections of scalp
  • Treats fungal infection of toes and fingernails
  • Athlete’s foot

Mechanism of Action-

Terbinafine prevent the ergosterol formation which is the component of the fungal cell membrane by inhibiting the enzyme squalene epoxidase which is commonly known as squalene monooxygenase and prevents conversion of squalene into ergosterol thus leads to accumulation of squalene and weakening of the fungal cell wall.

Pharmacokinetics-

Absorption- It is absorbed orally
Protein Binding- It is about 99% bound to plasma proteins and commonly bound to serum albumin
Metabolism- Terbinafine undergoes oxidation
Excretion- Most of the drug is excreted via urine i.e. up to 80% whereas rest of the drug is excreted via feces.
  • Headache
  • Diarrhoea
  • Rashes
  • Itching
  • Change in taste
  • Nausea
  • Upset stomach
  • Contraindicated in liver disease
  • Contraindicated in known allergic reactions
  • Amiodarone
  • Cimetidine
  • Rifampin
  • Fluconazole
  • Ketoconazole